Design and synthesis of macrocycles with tuneable diameters and helical foldamers with customizable peripheral side chains

2025/01/01 by Saquib Farooq, Aurélien Crochet, Andreas F. M. Kilbinger · 2 voices
Biochemistry, Genetics and Molecular Biology · Chemistry · Materials Science · #Advanced Polymer Synthesis and Characterization #Chemical Synthesis and Analysis #Dendrimers and Hyperbranched Polymers

paper · pdf · doi:10.1039/d5sc04138d

openalex publication_date 2025/01/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/06/26

Abstract

a living chain-growth process. Our strategy enables the incorporation of diverse functional groups, including ethers, esters, acids, and amides, on the outer surfaces of the macrocycles or synthetic nanotubes. Circular dichroism (CD) spectroscopy confirmed the helical conformations of the polymers in solution. These macrocycles and foldamers present exciting opportunities for designing bioinspired membrane channels and functional nanotubes with tuneable hydrophobicity and cavity sizes, paving the way for innovative applications in nanotechnology and materials science.

Discussions

• Pleased to share our work, “Design and Synthesis of Macrocycles with Tuneable Diameters and Helical Foldamers with Customizable Peripheral Side Chains”- now published in Chemical Science doi.org/10.10 [bsky, 2 points, 0 comments]
• Today's daily morning seminar doi.org/10.1039/d5sc... [bsky, 0 points, 0 comments]

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