2024/06/25 by Yu Jung Choi, Han-Na Kim, J. Lee +7 · 1 voice
Biochemistry, Genetics and Molecular Biology · Medicine · #Dermatological and COVID-19 studies #Inflammasome and immune disorders #Streptococcal Infections and Treatments
paper · pdf · doi:10.1016/j.ijid.2024.107152
openalex publication_date 2024/06/25 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/28
Erythema nodosum (EN) is a skin manifestation of panniculitis characterized by symmetric, painful, tender nodules, and most cases are self-limiting. Few cases of EN following Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) vaccination have been reported, and they are generally self-limiting. We reported the challenging case of a 63-year-old Asian woman with EN that persisted for more than three months after a coronavirus disease-19 (COVID-19). There was no improvement despite topical steroid and NSAIDs treatment, and the patient was successfully treated with combination of high-dose steroid and NSAIDs. There were long-lasting symptoms involving various organ symptoms persisting over three months after COVID-19, which is known as Long COVID. As part of Long COVID, there are limited cases of skin manifestations. Given that immune dysregulation due to persistent coronaviruses may contribute to refractory EN, Erythema nodosum related to COVID-19 is rare, but can occur; clinicians should be aware of the occurrence of EN following COVID-19 infection.