2001/08/01 by Mark L. Mitchell, Marciana D. Filippone, Timothy F. Wozniak · 1 citation
Medicine · Nursing · #Hemoglobinopathies and Related Disorders #Iron Metabolism and Disorders #Trace Elements in Health
paper · doi:10.5858/2001-125-1084-mccahh
crossref issued 2001/08/01 · crossref published 2001/08/01 · crossref published-print 2001/08/01 · openalex publication_date 2001/08/01 · crossref created 2021/01/29 · openalex created_date 2025/10/10 · crossref deposited 2026/02/11 · openalex updated_date 2026/06/11 · crossref indexed 2026/07/29
A 38-year-old woman had a mastectomy for infiltrating ductal carcinoma of the breast 3 years before her last admission and had received chemotherapy for known liver metastases. She developed the rapid onset of liver failure with portal hypertension and died in a hospice. Autopsy revealed macronodular cirrhosis of the liver secondary to metastatic carcinoma of the breast with associated florid fibrosis. This rare lesion, previously called metastatic carcinomatous cirrhosis, was also found, in this case, to have marked hepatic hemosiderosis, and analysis of the patient's DNA showed heterozygosity for the H63D genotype. The possibility of cirrhosis-associated hemosiderosis secondary to an iron metabolism abnormality associated with the H63D mutation of the HFE gene is proposed. Computed tomographic scans showed the development of cirrhosis during the 3-month period before the patient's last admission and suggested the possibility of a postnecrotic type origin.