2025/03/01 by Terri L. Holmes, Alzbeta Chabronova, Chris Denning +3 · 1 voice
Biochemistry, Genetics and Molecular Biology · #Cancer-related molecular mechanisms research #Genetic Syndromes and Imprinting #RNA modifications and cancer
paper · pdf · doi:10.1098/rsob.240371
openalex publication_date 2025/03/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/31
The small nucleolar RNA (snoRNA) SNORD116 is a small non-coding RNA of interest across multiple biomedical fields of research. Much of the investigation into SNORD116 has been undertaken in the context of the congenital disease Prader-Willi syndrome, wherein SNORD116 expression is lost. However, emerging evidence indicates wider roles in various disease and tissue contexts such as cellular growth, metabolism and signalling. Nevertheless, a conclusive mechanism of action for SNORD116 remains to be established. Here, we review the key findings from these investigations, with the aim of identifying common elements from which to elucidate potential targets and mechanisms of SNORD116. A key recurring element identified is disruption to the insulin/IGF-1 and PI3K/mTOR signalling pathways, contributing to many of the phenotypes associated with SNORD116 modulation explored in this review.