2024/09/12 by Huayang Li, Quan Liu, Chi-Yu Liu +11
Medicine · #Pulmonary Hypertension Research and Treatments
paper · doi:10.1165/rcmb.2023-0428oc
openalex publication_date 2024/09/12 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/25
Abstract Pulmonary hypertension (PH) is a life-threatening condition characterized by pulmonary vascular remodeling and endothelial dysfunction. Current therapies primarily target vasoactive imbalances but often fail to address adverse vascular remodeling. Long noncoding RNAs (lncRNAs), which are key regulators of various cellular processes, remain underexplored in the context of PH. To investigate the role of lncRNA in PH, we performed a comprehensive analysis using weighted gene coexpression network analysis on the GSE113439 dataset, comprising human lung tissue samples from different PH subtypes. Our analysis identified the lncRNA SNHG11 as consistently downregulated in PH. Functional assays in human pulmonary artery endothelial cells demonstrated that SNHG11 plays a critical role in modulating inflammation, cell proliferation, apoptosis, and the Janus kinase/signal transducers and activators of transcription and mitogen-activated protein kinase signaling pathways. Mechanistically, SNHG11 influences the stability of PRPF8, a crucial mRNA spliceosome component, thereby affecting multiple cellular functions beyond splicing. In vivo experiments using a hypoxic rat model showed that knockdown of SNHG11 alleviates PH development and improves right ventricular function. These findings highlight SNHG11 as a key regulator in PH pathogenesis and suggest it as a potential therapeutic target.