Trehalose Inhibits Human Immunodeficiency Virus Type 1 Infection in Primary Human Macrophages and CD4 + T Lymphocytes through Two Distinct Mechanisms

2020/06/17 by Pratima Rawat, Simson Hon, Carmen Teodorof‐Diedrich +1 · 1 voice · 1 citation
Immunology and Microbiology · Medicine · #Autophagy in Disease and Therapy #HIV Research and Treatment #HIV/AIDS Research and Interventions

paper · pdf · doi:10.1128/jvi.00237-20

openalex publication_date 2020/06/17 · openalex created_date 2020/06/25 · openalex updated_date 2026/08/01

Abstract

Induction of autophagy through inhibition of MTOR has been shown to inhibit HIV replication. However, inhibition of the mechanistic target of rapamycin (MTOR) has cellular effects that may alter HIV infection through other mechanisms. Here, we examined the HIV-inhibitory effects of the MTOR-independent inducer of autophagy, trehalose. Of note, we identified that in addition to the inhibition of the intracellular replication of HIV by autophagy, trehalose decreased viral entry in human primary macrophages and CD4 + T cells through the downregulation of C-C motif chemokine receptor 5 (CCR5) in T cells and CD4 in both T cells and macrophages. Thus, we showed that trehalose uniquely inhibits HIV replication through inhibition of viral entry and intracellular degradation in the two most important target cells for HIV infection.

Citations

• Human Immunodeficiency Virus Type 1 Nef Inhibits Autophagy through Transcription Factor EB Sequestration
• AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1
• mTOR regulation of autophagy
• Trehalose, a Novel mTOR-independent Autophagy Enhancer, Accelerates the Clearance of Mutant Huntingtin and α-Synuclein
• Regulation Mechanisms and Signaling Pathways of Autophagy
• Lithium induces autophagy by inhibiting inositol monophosphatase
• Insect Fat Body: Energy, Metabolism, and Regulation

Cited by

• Trehalose: A Promising Therapeutic Agent for Diverse Pathological Conditions

Discussions

• This appears to be a novel combination of already-published components, but I would frame that cautiously: I have not found a published study that combines all three in a J-Lat or primary CD4+ HIV lat [stackexchange, 3 points]

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