2025/01/01 by Kristýna Kolouchová, Nele Pien, Nalan Fatma Cetin +7 · 1 voice · 1 citation
Materials Science · Chemistry · #Nanoparticle-Based Drug Delivery #Lanthanide and Transition Metal Complexes #Advanced Polymer Synthesis and Characterization
paper · pdf · doi:10.1039/d5nr02033f
openalex publication_date 2025/01/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/02
-isopropylacrylamide) (PNIPAM) and poly(5-acrylamido-2,4,6-triiodoisophthalic acid) (PAATIPA), designed to combine radiopacity with drug delivery capabilities. PAATIPA's high iodine content provides strong contrast in CT scans, while PNIPAM's thermoresponsiveness allows for self-assembly at higher temperatures. The anionic nature of PAATIPA allows the efficient encapsulation of the cationic small-molecule rhodamine 6G. The copolymers exhibited an enhanced encapsulation of cationic rhodamine 6G (>90% at 35 w/w% of rhodamine) and excellent biocompatibility, as demonstrated in cytotoxicity assays. This study emphasizes the potential of PAATIPA-based copolymer materials as multifunctional, radio-opaque and stimuli-responsive materials for theranostic applications.