2026/02/26 by Georgy Kurakin · 1 voice
Medicine · Biochemistry, Genetics and Molecular Biology · #Cystic Fibrosis Research Advances #Neonatal Respiratory Health Research #Bacterial biofilms and quorum sensing
paper · pdf · doi:10.20944/preprints202602.1829.v1
openalex publication_date 2026/02/26 · openalex created_date 2026/02/28 · openalex updated_date 2026/07/31
Cystic fibrosis transmembrane conductance regulator (CFTR) is a chloride channel in humans and other vertebrates, whose mutation leads to cystic fibrosis. CFTR inhibitory factor — Cif — is a recently discovered bacterial epoxide hydrolase that downregulates CFTR protein upon the bacterial infection. However, its cleaving activity towards fatty acid epoxides — epoxygenase-derived oxylipins — has been recently characterized. We identified a list of host-associated bacteria with putative Cif proteins, identified their most prevalent ecological functions by systematic literature review, and performed similar review for the previously assembled list of host-associated bacteria carrying lipoxygenase (LOX). Both Cif and LOX showed the association with pathogenesis and symbiosis in broad host range, and similar ecological profiles of their carriers suggested that they both might target oxylipin signaling in hosts. We also described the association of Cif with plant hormone biosynthesis and plant growth promotion — which indirectly supports our previous model of bacterial LOX action in plant and vertebrate hosts.