Characteristics of SARS-CoV-2 and COVID-19

2020/10/06 by Ben Hu, Hua Guo, Peng Zhou +1 · 17 citations
Medicine · #COVID-19 Clinical Research Studies #SARS-CoV-2 and COVID-19 Research #Viral gastroenteritis research and epidemiology

paper · pdf · doi:10.1038/s41579-020-00459-7

openalex publication_date 2020/10/06 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/31

Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a highly transmissible and pathogenic coronavirus that emerged in late 2019 and has caused a pandemic of acute respiratory disease, named ‘coronavirus disease 2019’ (COVID-19), which threatens human health and public safety. In this Review, we describe the basic virology of SARS-CoV-2, including genomic characteristics and receptor use, highlighting its key difference from previously known coronaviruses. We summarize current knowledge of clinical, epidemiological and pathological features of COVID-19, as well as recent progress in animal models and antiviral treatment approaches for SARS-CoV-2 infection. We also discuss the potential wildlife hosts and zoonotic origin of this emerging virus in detail. In this Review, Shi and colleagues summarize the exceptional amount of research that has characterized acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and coronavirus disease 2019 (COVID-19) since this virus has swept around the globe. They discuss what we know so far about the emergence and virology of SARS-CoV-2 and the pathogenesis and treatment of COVID-19.

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Cited by

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• The Intersection of SARS-CoV-2 and Diabetes
• Total-Body Multiparametric PET Quantification of ¹⁸ F-FDG Delivery and Metabolism in the Study of Coronavirus Disease 2019 Recovery
• Discovery of the Clinical Candidate <b>S-892216</b> : A Second-Generation of SARS-CoV-2 3CL Protease Inhibitorfor Treating COVID-19
• ORFeome Phage Display Reveals a Major Immunogenic Epitope on the S2 Subdomain of SARS-CoV-2 Spike Protein
• A comprehensive review of current insights into the virulence factors of SARS-CoV-2
• The risk of COVID-19 death is much greater and age dependent with type I IFN autoantibodies
• Neutralizing nanobodies against SARS-CoV-2 recognizing highly conserved epitopes at the Spike’s S2 subunit
• <i>In silico</i> discovery of novel quinazolin-4-one derivatives as potent 3CLpro inhibitors using 2D-QSAR, molecular docking, and molecular dynamics
• Preparedness and Response Considerations for High-Consequence Infectious Disease
• SARS-CoV-2 variant biology: immune escape, transmission and fitness
• Learning from COVID-19 for Climate-Ready Urban Transformation
• Design, Synthesis, and Unprecedented Interactions of Covalent Dipeptide-Based Inhibitors of SARS-CoV-2 Main Protease and Its Variants Displaying Potent Antiviral Activity
• At-home testing for respiratory viruses: a minireview of the current landscape
• Health systems resilience in managing the COVID-19 pandemic: lessons from 28 countries
• "A 6 or a 9?": Ensemble Learning Through the Multiplicity of Performant Models and Explanations
• Identification of a novel lineage bat SARS-related coronaviruses that use bat ACE2 receptor

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