The Physiology, Pathology, and Potential Therapeutic Applications of the TREM2 Signaling Pathway

2020/06/01 by Aleksandra Deczkowska, Assaf Weiner, Ido Amit · 11 citations
Immunology and Microbiology · Neuroscience · #Inflammation biomarkers and pathways #Neuroinflammation and Neurodegeneration Mechanisms

paper · pdf · doi:10.1016/j.cell.2020.05.003

crossref issued 2020/06/01 · crossref published 2020/06/01 · crossref published-print 2020/06/01 · openalex publication_date 2020/06/01 · crossref created 2020/06/11 · crossref deposited 2025/09/25 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/29 · crossref indexed 2026/07/31

Citations

• Microglia in Alzheimer’s disease
• TREM2 Regulates Microglial Cholesterol Metabolism upon Chronic Phagocytic Challenge
• Human and mouse single-nucleus transcriptomics reveal TREM2-dependent and TREM2-independent cellular responses in Alzheimer’s disease
• Construction of a human cell landscape at single-cell level

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• Clinical relevance of tumour-associated macrophages
• Biophysical mapping of TREM2-ligand interactions reveals shared surfaces for engagement of multiple Alzheimer’s disease ligands
• Macrophage-targeted immunocytokine leverages myeloid, T, and NK cell synergy for cancer immunotherapy
• BTK regulates microglial function and neuroinflammation in human stem cell models and mouse models of multiple sclerosis
• Soluble TREM2 engages cell-surface nucleolin to drive vascular permeability and malignant ascites in ovarian cancer
• Microglia as Double-Edged Players in Ischemic Stroke
• Ethanol induces neuroimmune dysregulation and soluble TREM2 generation in a human iPSC neuron, astrocyte, microglia triculture model
• GDI2 deletion alleviates neurodegeneration and memory loss in the 5xFAD mice model of Alzheimer's disease