Clinical relevance of tumour-associated macrophages

2022/03/30 by Mikael J. Pittet, Mikaël J. Pittet, Olivier Michielin +1 · 10 citations
Immunology and Microbiology · #Immune Cell Function and Interaction #Immune cells in cancer #Phagocytosis and Immune Regulation

paper · doi:10.1038/s41571-022-00620-6

crossref issued 2022/03/30 · crossref published 2022/03/30 · crossref published-online 2022/03/30 · openalex publication_date 2022/03/30 · crossref created 2022/03/30 · crossref published-print 2022/06/01 · crossref deposited 2023/01/30 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/29 · crossref indexed 2026/07/30

Citations

• IL-12 Release by Engineered T Cells Expressing Chimeric Antigen Receptors Can Effectively Muster an Antigen-Independent Macrophage Response on Tumor Cells That Have Shut Down Tumor Antigen Expression
• Single-Cell Mapping of Human Brain Cancer Reveals Tumor-Specific Instruction of Tissue-Invading Leukocytes
• The Physiology, Pathology, and Potential Therapeutic Applications of the TREM2 Signaling Pathway
• TREM2 Modulation Remodels the Tumor Myeloid Landscape Enhancing Anti-PD-1 Immunotherapy
• Obesity Shapes Metabolism in the Tumor Microenvironment to Suppress Anti-Tumor Immunity
• Liver metastasis restrains immunotherapy efficacy via macrophage-mediated T cell elimination
• A pan-cancer single-cell transcriptional atlas of tumor infiltrating myeloid cells
• Therapeutic Targeting of the Tumor Microenvironment
• Single-cell profiling of myeloid cells in glioblastoma across species and disease stage reveals macrophage competition and specialization
• Cross-tissue single-cell landscape of human monocytes and macrophages in health and disease
• Exploring tissue architecture using spatial transcriptomics
• A single-cell and spatially resolved atlas of human breast cancers

Cited by

• Macrophages in immunoregulation and therapeutics
• The evolving tumor microenvironment: From cancer initiation to metastatic outgrowth
• Spatial single-cell proteotyping reveals immunotherapy-resistant features within the complex tumor microenvironment of metastatic NSCLC
• Myeloid cells in the era of cancer immunotherapy: Top 3 unanswered questions
• NF-κB in biology and targeted therapy: new insights and translational implications
• Macrophages restrict tumor permissiveness to immune infiltration by controlling local collagen topography through a Tcf4-Collagen3 fibrotic axis
• Single-cell RNA sequencing: a powerful tool to study heterogeneity in papillary and anaplastic thyroid carcinoma
• Class A scavenger receptors promote tumor progression and induce a unique macrophage phenotype in a mouse model of spontaneous breast cancer
• Tumor-associated macrophages in cancer: from mechanisms to application
• Hallmarks of cancer—Then and now, and beyond