2020/01/04 by Siming Huang, Xiaoxue Kou, Jun Shen +2 · 3 citations
Chemistry · Materials Science · #Advanced Nanomaterials in Catalysis #Mass Spectrometry Techniques and Applications #Metal-Organic Frameworks: Synthesis and Applications
paper · doi:10.1002/anie.201916474
openalex publication_date 2020/01/04 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/28
Cell-free enzymatic catalysis (CFEC) is an emerging biotechnology that enable the biological transformations in complex natural networks to be imitated. This biomimetic approach allows industrial products such as biofuels and biochemical to be manufactured in a green manner. Nevertheless, the main challenge in CFEC is the poor stability, which restricts the effectiveness and lifetime of enzymes in sophisticated applications. Immobilization of the enzymes within solid carriers is considered an efficient strategy for addressing these obstacles. Specifically, putting an "armor-like" porous metal-organic framework (MOF) exoskeleton tightly around the enzymes not only shields the enzymes against external stimulus, but also allows the selective transport of guests through the accessible porous network. Herein we present the concept of this biotechnology of MOF-entrapped enzymes and its cutting-edge applications.