2023/04/12 by Kunyu Wang, Jiaqi Zhang, Yu‐Chuan Hsu +7 · 8 citations
Chemistry · Materials Science · #Metal-Organic Frameworks: Synthesis and Applications #Supramolecular Chemistry and Complexes #Supramolecular Self-Assembly in Materials
paper · doi:10.1021/acs.chemrev.2c00879
openalex publication_date 2023/04/12 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/28
Enzymatic catalysis has fueled considerable interest from chemists due to its high efficiency and selectivity. However, the structural complexity and vulnerability hamper the application potentials of enzymes. Driven by the practical demand for chemical conversion, there is a long-sought quest for bioinspired catalysts reproducing and even surpassing the functions of natural enzymes. As nanoporous materials with high surface areas and crystallinity, metal-organic frameworks (MOFs) represent an exquisite case of how natural enzymes and their active sites are integrated into porous solids, affording bioinspired heterogeneous catalysts with superior stability and customizable structures. In this review, we comprehensively summarize the advances of bioinspired MOFs for catalysis, discuss the design principle of various MOF-based catalysts, such as MOF-enzyme composites and MOFs embedded with active sites, and explore the utility of these catalysts in different reactions. The advantages of MOFs as enzyme mimetics are also highlighted, including confinement, templating effects, and functionality, in comparison with homogeneous supramolecular catalysts. A perspective is provided to discuss potential solutions addressing current challenges in MOF catalysis.