Mitochondrial electron transport chain: Oxidative phosphorylation, oxidant production, and methods of measurement

2020/08/06 by Deirdre Nolfi‐Donegan, Andrea Braganza, Sruti Shiva · 9 citations
Biochemistry, Genetics and Molecular Biology · #Mitochondrial Function and Pathology #ATP Synthase and ATPases Research #Coenzyme Q10 studies and effects

paper · doi:10.1016/j.redox.2020.101674

openalex publication_date 2020/08/06 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/31

Abstract

The mitochondrial electron transport chain utilizes a series of electron transfer reactions to generate cellular ATP through oxidative phosphorylation. A consequence of electron transfer is the generation of reactive oxygen species (ROS), which contributes to both homeostatic signaling as well as oxidative stress during pathology. In this graphical review we provide an overview of oxidative phosphorylation and its inter-relationship with ROS production by the electron transport chain. We also outline traditional and novel translational methodology for assessing mitochondrial energetics in health and disease.

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