Förster resonance energy transfer (FRET)-based small-molecule sensors and imaging agents

2020/01/01 by Luling Wu, Chusen Huang, Ben P. Emery +7 · 5 citations
Chemistry · Materials Science · Biochemistry, Genetics and Molecular Biology · #Molecular Sensors and Ion Detection #Luminescence and Fluorescent Materials #Advanced biosensing and bioanalysis techniques

paper · doi:10.1039/c9cs00318e

openalex publication_date 2020/01/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/28

Abstract

In this tutorial review, we will explore recent advances in the construction and application of Förster resonance energy transfer (FRET)-based small-molecule fluorescent probes. The advantages of FRET-based fluorescent probes include: a large Stokes shift, ratiometric sensing and dual/multi-analyte responsive systems. We discuss the underlying energy donor-acceptor dye combinations and emphasise their applications for the detection or imaging of cations, anions, small neutral molecules, biomacromolecules, cellular microenvionments and dual/multi-analyte responsive systems.

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