Advances in oligonucleotide drug delivery

2020/08/11 by Thomas C. Roberts, Robert Langer, Róbert Langer +1 · 18 citations
Biochemistry, Genetics and Molecular Biology · #Advanced biosensing and bioanalysis techniques #MicroRNA in disease regulation #RNA Interference and Gene Delivery

paper · pdf · doi:10.1038/s41573-020-0075-7

crossref issued 2020/08/11 · crossref published 2020/08/11 · crossref published-online 2020/08/11 · openalex publication_date 2020/08/11 · crossref created 2020/08/11 · crossref published-print 2020/10/01 · crossref deposited 2024/12/11 · openalex created_date 2025/10/10 · crossref indexed 2026/07/30 · openalex updated_date 2026/07/31

Citations

• A Programmable Dual-RNA–Guided DNA Endonuclease in Adaptive Bacterial Immunity
• Cobomarsen, an oligonucleotide inhibitor of miR‐155, co‐ordinately regulates multiple survival pathways to reduce cellular proliferation and survival in cutaneous T‐cell lymphoma
• The biology , function , and biomedical applications of exosomes

Cited by

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• The current landscape of nucleic acid therapeutics
• RNA-binding proteins in human genetic disease
• Drug delivery systems for RNA therapeutics
• Aptamer-conjugated gold nanoparticles enable oligonucleotide delivery into muscle stem cells to promote regeneration of dystrophic muscles
• Molecular and therapeutic frontiers in anemia therapy
• Promoter-targeted small RNA duplexes increase MBNL1 transcription and mitigate myotonic dystrophy-associated spliceopathy
• Durable suppression of seizures in a preclinical model of KCNT1 genetic epilepsy with divalent small interfering RNA
• Understanding the fundamentals of the on-off retention mechanism of oligonucleotides and their application to high throughput analysis
• 2024 VCP International Conference: Exploring multi-disciplinary approaches from basic science of valosin containing protein, an AAA+ ATPase protein, to the therapeutic advancement for VCP-associated multisystem proteinopathy
• Selective mRNA translation determines adaptative mutability of melanoma cells to anti-BRAF/MEK combination therapy
• In vivo and ex vivo gene therapy for neurodegenerative diseases: a promise for disease modification
• The emerging roles of long non-coding RNAs in the nervous system
• A Review on Polymer and Lipid-Based Nanocarriers and Its Application to Nano-Pharmaceutical and Food-Based Systems
• Modulating T-cell activation with antisense oligonucleotides targeting lymphocyte cytosolic protein 2
• Progress and prospects in antisense oligonucleotide-mediated exon skipping therapies for Duchenne muscular dystrophy
• An antagomiR-loaded β-peptide hydrogel promotes functional recovery in mice post-ischaemic stroke
• A therapeutic antisense oligonucleotide encompassing 2′- O -methoxyethyl modification triggers unique perturbation of the transcriptome