Chondroitin sulfate proteoglycan Windpipe modulates Hedgehog signaling in Drosophila

2020/04/01 by Masahiko Takemura, Fredrik Noborn, Jonas Nilsson +6

paper · doi:10.1091/mbc.e19-06-0327

Abstract

Using a recently developed glycoproteomic method, we identified a novel chondroitin sulfate proteoglycan, Windpipe (Wdp), in Drosophila. Wdp has three chondroitin sulfate sugar chains on the extracellular domain. We show that Wdp negatively regulates Hedgehog signaling via the chondroitin sulfate sugar chains.

Related

• The Adventures of Sonic Hedgehog in Development and Repair. III. Hedgehog processing and biological activity
• Plexins promote Hedgehog signaling through their cytoplasmic GAP activity
• Functions of Cell Surface Heparan Sulfate Proteoglycans
• The Inseparable Relationship Between Cholesterol and Hedgehog Signaling
• Cholesterylation: a tail of hedgehog