2015/04/01 by Paulina Ciepla, Anthony I. Magee, Anthony I. Magee +2
Biochemistry, Genetics and Molecular Biology · #Epigenetics and DNA Methylation #Genomics and Chromatin Dynamics #Hedgehog Signaling Pathway Studies
paper · doi:10.1042/bst20150032
openalex publication_date 2015/04/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/31
Cholesterylation is a post-translational attachment of sterol to proteins. This modification has been a characteristic of a single family of hedgehog proteins (Hh). Hh is a well-established morphogenic molecule important in embryonic development. It was also found to be involved in the progression of many cancer types. Herein, we describe the mechanism of biosynthesis of cholesterylated Hh, the role of this unusual modification on protein functions and novel chemical probes, which could be used to specifically target this modification, both in vitro and in vivo.