2018/12/01 by Henry N. Higgs
Biochemistry, Genetics and Molecular Biology · Physics and Astronomy · #Advanced Fluorescence Microscopy Techniques #Cellular Mechanics and Interactions #Force Microscopy Techniques and Applications
paper · doi:10.1091/mbc.e18-07-0426
openalex publication_date 2018/12/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/05/21
A fundamental question in cell biology concerns how cells move, and this has been the subject of intense research for decades. In the 1990s, a major leap forward was made in our understanding of cell motility, with the proposal of the dendritic nucleation model. This essay describes the events leading to the development of the model, including findings from many laboratories and scientific disciplines. The story is an excellent example of the scientific process in action, with the combination of multiple perspectives leading to robust conclusions.