2024/01/16 by Conboy, James P., Petitjean, Irene Istúriz, van der Net, Anouk +1 · 2 citations
#Biological Physics (physics.bio-ph) #Cell Behavior (q-bio.CB) #FOS: Biological sciences #FOS: Physical sciences
paper · doi:10.48550/arxiv.2401.08368
Cell migration is a fundamental process for life and is highly dependent on the dynamical and mechanical properties of the cytoskeleton. Intensive physical and biochemical crosstalk between actin, microtubules, and intermediate filaments ensures their coordination to facilitate and enable migration. In this review we discuss the different mechanical aspects that govern cell migration and provide, for each mechanical aspect, a novel perspective by juxtaposing two complementary approaches to the biophysical study of cytoskeletal crosstalk: live-cell studies (often referred to as top-down studies) and cell-free studies (often referred to as bottom-up studies). We summarize the main findings from both experimental approaches, and we provide our perspective on bridging the two perspectives to address the open questions of how cytoskeletal crosstalk governs cell migration and makes cells move.