2015/04/14 by Shawn Marshall, Mark Bayley, Scott McCullagh +4 · 3 citations
Biochemistry, Genetics and Molecular Biology · Medicine · #S100 Proteins and Annexins #Traumatic Brain Injury Research #Traumatic Brain Injury and Neurovascular Disturbances
paper · doi:10.3109/02699052.2015.1004755
openalex publication_date 2015/04/14 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/25
OBJECTIVE: To introduce a set of revised guidelines for the management of mild traumatic brain injury (mTBI) and persistent symptoms following concussive injuries. QUALITY OF EVIDENCE: The Guidelines for Mild Traumatic Brain Injury and Persistent Symptoms were made available in March 2011 based on literature and information up to 2008. A search for new clinical practice guidelines addressing mTBI and a systematic review of the literature evaluating treatment of persistent symptoms was conducted. Healthcare professionals representing a range of disciplines from Canada and abroad attended a consensus conference to revise the original guidelines in light of new evidence. MAIN MESSAGE: A modified Delphi process was used to create 96 recommendations addressing the diagnosis and management of mTBI and persistent symptoms, including post-traumatic headache, sleep disturbances, mental health disorders, cognitive difficulties, vestibular and vision dysfunction, fatigue and return to activity/work/school. Numerous resources, tools and treatment algorithms were also included to aid implementation of the recommendations. CONCLUSION: The revised clinical practice guideline reflects the most current evidence and is recommended for use by clinicians who provide care to people who experience PPCS following mTBI.