Small airway fibroblasts from patients with chronic obstructive pulmonary disease exhibit cellular senescence

2023/12/27 by Catherine L. Wrench, Catherine Wrench, Jonathan R. Baker +9 · 4 citations
Medicine · #Chronic Obstructive Pulmonary Disease (COPD) Research #Neonatal Respiratory Health Research #Telomeres, Telomerase, and Senescence

paper · doi:10.1152/ajplung.00419.2022

openalex publication_date 2023/12/27 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/30

Abstract

Fibroblasts and senescence are thought to play key roles in the pathogenesis of small airway disease and COPD; however, the characteristics of small airway-derived fibroblasts are not well explored. In this study we isolate and enrich the senescent small airway-derived fibroblast (SAF) population from COPD lungs and explore the pathways driving this phenotype using bulk RNA-seq.

Citations

• The Contribution of Small Airway Obstruction to the Pathogenesis of Chronic Obstructive Pulmonary Disease

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