High-fat diet obesity exacerbates acute lung injury-induced dysregulation of fatty acid oxidation in alveolar epithelial type 2 cells

2025/07/23 by Eleni Kallinos, Kuei‐Pin Chung, Kuei-Pin Chung +10 · 1 citation
Medicine · #Chronic Obstructive Pulmonary Disease (COPD) Research #Neonatal Respiratory Health Research #Respiratory Support and Mechanisms

paper · doi:10.1152/ajplung.00406.2024

openalex publication_date 2025/07/23 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/31

Abstract

High-fat diet obesity is linked to increased lung injury and bronchoalveolar lavage fluid (BALF) fatty acids in a hyperoxic ARDS model. In the present study, obesity not only upregulated intracellular lipids and effectors of fatty acid mitochondrial import but also was associated with downregulated fatty acid oxidation and reduced ATP production in alveolar epithelial type 2 cells after injury. Hyperoxic AEC2 from obese mice had reduced phospholipids, and obese mice had increased BALF surface tension after injury.

Cited by

• Are alveolar type 2 cells “oversaturated” in obesity and ARDS?

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