2025/05/27 by William G. Tharp, Carlos A. Gartner, Yulica Santos-Ortega +4
Medicine · #Adipokines, Inflammation, and Metabolic Diseases #Chronic Obstructive Pulmonary Disease (COPD) Research
paper · doi:10.1152/ajplung.00054.2025
openalex publication_date 2025/05/27 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/01
Obesity is thought to cause deleterious changes in lung biochemistry, but data in humans are lacking. We measured the alveolar proteome in bronchoalveolar lavages from subjects with a wide range of body mass index and no lung disease. We found changes in proteins and pathways associated with increasing body mass index that are similar to pathological changes observed in other tissues and may constitute mechanisms of pulmonary dysfunction in obesity.