Role of voltage-gated Ca 2+ channels and Ano1 Ca 2+ -activated Cl − channels in M2 muscarinic receptor-dependent contractions of murine airway smooth muscle

2025/01/08 by Srijit Ghosh, Tuleen Alkawadri, Lorcan McGarvey +5
Biochemistry, Genetics and Molecular Biology · Neuroscience · #Ion Channels and Receptors #Ion channel regulation and function #Nicotinic Acetylcholine Receptors Study

paper · doi:10.1152/ajplung.00188.2024

openalex publication_date 2025/01/08 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/30

Abstract

The role of L-type Ca 2+ channels and Ano1 Ca 2+ -activated Cl − channels in cholinergic contractions of airway smooth muscle is disputed. Here, we show that both channels are involved in M2 muscarinic receptor-dependent contractions of murine airway smooth muscle via inhibition of buffering of Ca 2+ influx by sarcoplasmic endoplasmic reticulum Ca 2+ ATPases.

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