Involvement of ryanodine receptors in the contraction of small pulmonary veins

2025/04/04 by Francisca Varas, Marcelo Fonseca, Natalia Astudillo +7
Biochemistry, Genetics and Molecular Biology · Chemistry · Medicine · #Asthma and respiratory diseases #Electrochemical Analysis and Applications #Ion Transport and Channel Regulation

paper · doi:10.1152/ajplung.00375.2024

openalex publication_date 2025/04/04 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/28

Abstract

The results indicate that RyR2 would be the most relevant isoform in SPV contraction induced by depolarization, whereas RyR1 and RyR3 would participate in the contractile mechanism induced by GqPCR agonists. It is worth noting that based on the scRNA seq studies, RyR1 was shown to be the less expressed isoform in SMCs in the rat lung, which indicates that RyR2 and RyR3 may be the most relevant isoforms participating in the contraction of SPV.

Citations

• A molecular cell atlas of the human lung from single-cell RNA sequencing

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