Intraamniotic vitamin D preserves lung development and prevents pulmonary hypertension in experimental bronchopulmonary dysplasia due to intraamniotic sFlt-1

2025/03/24 by Michael W. Cookson, Tania Gonzalez, Tania González +6
Medicine · #Neonatal Respiratory Health Research #Congenital Diaphragmatic Hernia Studies #Chronic Obstructive Pulmonary Disease (COPD) Research

paper · pdf · doi:10.1152/ajplung.00409.2024

Abstract

This study highlights that experimental BPD induced by intraamniotic sFlt-1 is associated with impaired growth in postnatal pulmonary endothelial cells. We demonstrate that 1,25(OH) 2 D may be a therapeutic option to improve lung development through enhancement of VEGF signaling and preservation of early pulmonary endothelial growth in the newborn rat lung.

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