Direct or indirect action mechanisms of Naringin in maintaining bone homeostasis

2023/06/30 by Xianghu Zhao, Jing Hu, Jing Hu +12
Biochemistry, Genetics and Molecular Biology · Chemistry · Pharmacology, Toxicology and Pharmaceutics · #Phosphodiesterase function and regulation #Phytochemistry and Bioactivity Studies #Synthesis and biological activity

paper · pdf · doi:10.14715/cmb/2023.69.6.23

openalex publication_date 2023/06/30 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/31

Abstract

Disruption of bone homeostasis is the pathological basis of bone diseases. Multiple cells work together to maintain homeostasis and bone health. As a natural flavonoid compound, Naringin (NG) can positively affect the maintenance of bone homeostasis by acting on different types of cells. In this review, we discuss the direct and indirect osteoprotective effects of NG as well as the underlying mechanisms, and we provide a critical perspective on its clinical translation.

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