Identification of medication–microbiome interactions that affect gut infection

2025/07/16 by Aman Kumar, Ruizheng Sun, Bettina Habib +6 · 2 voices
Biochemistry, Genetics and Molecular Biology · Medicine · Agricultural and Biological Sciences · #Gut microbiota and health #Clostridium difficile and Clostridium perfringens research #Probiotics and Fermented Foods

paper · doi:10.1038/s41586-025-09273-8

Citations

• The Reactome Pathway Knowledgebase 2024
• Extending support for mouse data in the Molecular Signatures Database (MSigDB)
• Validation of Acute Gastroenteritis-related International Classification of Diseases, Clinical Modification Codes in Pediatric and Adult US Populations
• The SILVA ribosomal RNA gene database project: improved data processing and web-based tools

Discussions

• Over a million health records + mouse models reveal that common drugs like digoxin can disrupt the gut microbiome and boost infection risk by altering β-defensin expression. Cool interplay of host, bu [bsky, 7 points, 0 comments]
• 📊 Das Paper zeigt eindrucksvoll, wie Daten aus Epidemiologie und Tierversuchen kombiniert werden können, um neue Risiken im Zusammenspiel von Medikamenten, Darmbakterien und Infektionsanfälligkeit zu [bsky, 4 points, 0 comments]