The life cycle of the 26S proteasome: from birth, through regulation and function, and onto its death

2016/07/22 by Ido Livneh, Victoria Cohen-Kaplan, Victoria Cohen‐Kaplan +3 · 3 citations
Biochemistry, Genetics and Molecular Biology · Medicine · #Autophagy in Disease and Therapy #Endoplasmic Reticulum Stress and Disease #Ubiquitin and proteasome pathways

paper · pdf · doi:10.1038/cr.2016.86

openalex publication_date 2016/07/22 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/31

Abstract

The 26S proteasome is a large, ∼2.5 MDa, multi-catalytic ATP-dependent protease complex that serves as the degrading arm of the ubiquitin system, which is the major pathway for regulated degradation of cytosolic, nuclear and membrane proteins in all eukaryotic organisms.

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• Oversized cells activate global proteasome-mediated protein degradation to maintain cell size homeostasis
• Cryo-EM structures and dynamics of substrate-engaged human 26S proteasome

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