2023/08/28 by Aurélia Huyghe, Aneta Trajkova, Fabrice Lavial · 2 citations
Biochemistry, Genetics and Molecular Biology · #Epigenetics and DNA Methylation #Pluripotent Stem Cells Research #Renal and related cancers
paper · pdf · doi:10.1016/j.tcb.2023.07.013
openalex publication_date 2023/08/28 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/30
The multistep process of in vivo reprogramming, mediated by the transcription factors (TFs) Oct4, Sox2, Klf4, and c-Myc (OSKM), holds great promise for the development of rejuvenating and regenerative strategies. However, most of the approaches developed so far are accompanied by a persistent risk of tumorigenicity. Here, we review the groundbreaking effects of in vivo reprogramming with a particular focus on rejuvenation and regeneration. We discuss how the activity of pioneer TFs generates cellular plasticity that may be critical for inducing not only reprogramming and regeneration, but also cancer initiation. Finally, we highlight how a better understanding of the uncoupled control of cellular identity, plasticity, and aging during reprogramming might pave the way to the development of rejuvenating/regenerating strategies in a nontumorigenic manner.