Cross-talk between protein synthesis, energy metabolism and autophagy in cancer

2017/11/25 by Lisa M Lindqvist, Lisa Lindqvist, Kristofferson Tandoc +3 · 2 citations
Medicine · Biochemistry, Genetics and Molecular Biology · #Autophagy in Disease and Therapy #RNA modifications and cancer #Metabolism, Diabetes, and Cancer

paper · doi:10.1016/j.gde.2017.11.003

Abstract

Translation is a pivotal step in the regulation of gene expression as well as one of the most energy consuming processes in the cell. Dysregulation of translation caused by the aberrant function of upstream signaling pathways and/or perturbations in the expression or function of components of the translation machinery is frequent in cancer. In this review, we discuss emerging findings that highlight hitherto unappreciated aspects of signaling to the translation apparatus with the particular focus on emerging connections between protein synthesis, autophagy and energy homeostasis in cancer.

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