Fe(III)-Catalyzed Intermolecular C(sp²)-C(sp³) Dehydration Coupling Reaction of Ketene Dithioacetals and Propargyl Alcohols: Synthesis of Novel gem-Dialkylthiopenten-4-ynes and Further Conversion into Methyl Pent-4-ynoates

2011/09/27 by Jin-Na Song, Jinna Song, Peiqiu Liao +8
Chemistry · #Synthesis of heterocyclic compounds #Sulfur-Based Synthesis Techniques #Click Chemistry and Applications

paper · doi:10.1055/s-0030-1260333

Abstract

We report an iron(III)-catalyzed intermolecular C(sp²)-C(sp³) dehydration coupling reaction between ketene dithioacetals and propargyl alcohols, leading to the synthesis of gem-dialkylthiopenten-4-ynes in high efficiency. The products could be transformed into methyl pent-4-ynoates in high yields.

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