Periodontal disease and cancer: Epidemiologic studies and possible mechanisms

2020/05/08 by Ngozi Nwizu, Ngozi N. Nwizu, Jean Wactawski‐Wende +1 · 6 citations
Dentistry · Medicine · #HIV/AIDS oral health manifestations #Oral Health Pathology and Treatment #Oral microbiology and periodontitis research

paper · pdf · doi:10.1111/prd.12329

openalex publication_date 2020/05/08 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/30

Abstract

Epidemiologic and cancer control studies on the association of periodontal disease and cancer risk mostly suggest a positive association with overall cancer risk and certain specific types of cancer. These findings are generally consistent among cross-sectional and longitudinal studies. In this paper, we review epidemiologic studies and current knowledge on periodontal disease and cancer, with a focus on those studies conducted in the years following the Joint European Federation of Periodontology/American Academy of Periodontology Workshop on "Periodontitis and Systemic Diseases" in November 2012. This review also explores the role of chronic inflammation as a biologically plausible mechanistic link between periodontal disease and risk of cancer. Furthermore, it highlights studies that have examined the potential importance of certain periodontal pathogens in this association.

Citations

• Poor oral hygiene as a risk factor for infective endocarditis–related bacteremia
• Systemic Release of Endotoxins Induced by Gentle Mastication: Association With Periodontitis Severity

Cited by

• The Fossil Corbiculids from the Palaeogene Isikari Series in the Isikari Coal-Field, Hokkaidô
• Epidemiological associations between periodontitis and cancer
• Periodontitis and risk of cancer: Mechanistic evidence
• Associations Between Socioeconomic, Spatial and Educational Factors and Midlife Periodontal Disease Risk: Evidence From ‘High School and Beyond’
• Association between periodontitis and severity of COVID‐19 infection: A case–control study
• Oral microbiota in human systematic diseases
• The role of CRISPR‐Cas in advancing precision periodontics

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• Epidemiological associations between periodontitis and cancer
• Periodontitis and risk of cancer: Mechanistic evidence
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• Modifiable risk factors in periodontitis: at the intersection of aging and disease
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