2024/09/20 by Jonathan Higham, Jon Higham, Frank A. Scannapieco
Dentistry · Medicine · #Head and Neck Cancer Studies #Oral Health Pathology and Treatment #Oral microbiology and periodontitis research
paper · doi:10.1111/prd.12599
openalex publication_date 2024/09/20 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/30
There is a postulated association of periodontitis with a number of human cancers. This narrative review provides current epidemiological evidence on the association between periodontitis and cancer. A PubMed search with the relevant keywords (periodontal disease, periodontitis, cancer, and malignancy) was completed to identify relevent articles. We present a narrative review on the association between periodontal disease and a range of cancers, including oral cancer, stomach and esophageal cancer, colorectal cancer, lung cancer, pancreatic cancer, prostate cancer, hematological malignancies, liver cancer, breast cancer, and ovarian cancer. While there is a considerable body of epidemiological evidence that supports the association between periodontal disease and cancer, this is largely from cohort and case-control studies and the association may therefore be circumstantial as little evidence exists in the form of treatment trials that would validate the role of periodontal disease in the process of cancer initiation and development.