2019/07/18 by Nimisha Thakur, Rahul A. Patil, Mohsen Talebi +2
Chemistry · Engineering · #Analytical Chemistry and Chromatography #Asymmetric Hydrogenation and Catalysis #Surface Chemistry and Catalysis
paper · doi:10.1002/chir.23086
openalex publication_date 2019/07/18 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/25
The enantiomeric excess of chiral starting materials is one of the important factors determining the enantiopurity of products in asymmetric synthesis. Fifty-one commercially available chiral reagents used as building blocks, catalysts, and auxiliaries in various enantioselective syntheses were assayed for their enantiomeric purity. The test results were classified within five impurities level (ie, <0.01%, 0.01%-0.1%, 0.1%-1%, 1%-10%, >10%). Previously from 1998 to 2013, several reports have been published on the enantiomeric composition of more than 300 chiral reagents. This series of papers is necessitated by the fact that new reagents are forthcoming and that the enantiomeric purity of the same reagent can vary from batch to batch and/or from supplier to supplier. This report presents chiral liquid chromatography (LC) and gas chromatography (GC) methods to separate enantiomers of chiral compounds and evaluate their enantiomeric purities. The accurate and efficient LC analysis was done using newly introduced superficially porous particle (SPP 2.7 μm) based chiral stationary phases (TeicoShell, VancoShell, LarihcShell-P, and NicoShell).