Evaluation of aromatic-derivatized cyclofructans 6 and 7 as HPLC chiral selectors

2010/12/07 by Ping Sun, Chunlei Wang, Nilusha Padivitage +7 · 4 citations
Chemistry · Engineering · #Analytical Chemistry and Chromatography #Microfluidic and Capillary Electrophoresis Applications #Chromatography in Natural Products

paper · doi:10.1039/c0an00653j

Abstract

The two best aromatic-functionalized cyclofructan chiral stationary phases, R-naphthylethyl-carbamate cyclofructan 6 (RN-CF6) and dimethylphenyl-carbamate cyclofructan 7 (DMP-CF7), were synthesized and evaluated by injecting various classes of chiral analytes. They provided enantioselectivity toward a broad range of compounds, including chiral acids, amines, metal complexes, and neutral compounds. It is interesting that they exhibited complementary selectivities and the combination of two columns provided enantiomeric separations for 43% of the test analytes. These extensive chromatographic results provided useful information about method development of specific analytes, and also gave some insight as to the enantioseparation mechanism.

Cited by

• Enantiomeric separations of illicit drugs and controlled substances using cyclofructan-based (LARIHC) and cyclobond I 2000 RSP HPLC chiral stationary phases. [europepmc]
• Enantiomeric separation of biaryl atropisomers using cyclofructan based chiral stationary phases. [europepmc]
• PREPARATION AND EVALUATION OF HPLC CHIRAL STATIONARY PHASES BASED ON CATIONIC/BASIC DERIVATIVES OF CYCLOFRUCTAN 6. [europepmc]
• High performance affinity chromatography and related separation methods for the analysis of biological and pharmaceutical agents. [europepmc]

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