Mobile Oxazolidinone Resistance Genes in Gram-Positive and Gram-Negative Bacteria

2021/06/11 by Stefan Schwarz, Štefan Schwarz, Wanjiang Zhang +9 · 1 citation
Agricultural and Biological Sciences · Biochemistry, Genetics and Molecular Biology · Environmental Science · #Antibiotic Resistance in Bacteria #Microbial Community Ecology and Physiology #Probiotics and Fermented Foods

paper · doi:10.1128/cmr.00188-20

openalex publication_date 2021/06/11 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/30

Abstract

Seven mobile oxazolidinone resistance genes, including cfr , cfr (B), cfr (C), cfr (D), cfr (E), optrA , and poxtA , have been identified to date. The cfr genes code for 23S rRNA methylases, which confer a multiresistance phenotype that includes resistance to phenicols, lincosamides, oxazolidinones, pleuromutilins, and streptogramin A compounds. The optrA and poxtA genes code for ABC-F proteins that protect the bacterial ribosomes from the inhibitory effects of oxazolidinones.

Citations

• ARG-ANNOT, a New Bioinformatic Tool To Discover Antibiotic Resistance Genes in Bacterial Genomes
• ResFinder 4.0 for predictions of phenotypes from genotypes

Cited by

• Selection and maintenance of mobile linezolid-resistance genes and plasmids carrying them in the presence of florfenicol, an animal-specific antimicrobial

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