2024/06/22 by Joonho Suh, Yun-Sil Lee, Yun‐Sil Lee
Biochemistry, Genetics and Molecular Biology · Medicine · #ATP Synthase and ATPases Research #Adipose Tissue and Metabolism #Mitochondrial Function and Pathology
paper · pdf · doi:10.1093/jbmr/zjae088
openalex publication_date 2024/06/22 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/29
Mitochondria in osteoblasts have been demonstrated to play multiple crucial functions in bone formation from intracellular adenosine triphosphate production to extracellular secretion of mitochondrial components. The present review explores the current knowledge about mitochondrial biology in osteoblasts, including mitochondrial biogenesis, bioenergetics, oxidative stress generation, and dynamic changes in morphology. Special attention is given to recent findings, including mitochondrial donut formation in osteoblasts, which actively generates mitochondrial-derived vesicles (MDVs), followed by extracellular secretion of small mitochondria and MDVs. We also discuss the therapeutic effects of targeting osteoblast mitochondria, highlighting their potential applications in improving bone health.