MEGA X: Molecular Evolutionary Genetics Analysis across Computing Platforms
2018/05/01 by Sudhir Kumar, Glen Stecher, Michael Li +2 · 276 citations
Biochemistry, Genetics and Molecular Biology · Computer Science · #Evolution and Genetic Dynamics #Evolutionary Algorithms and Applications #Genomics and Phylogenetic Studies
paper · pdf · doi:10.1093/molbev/msy096
openalex publication_date 2018/05/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/04
Abstract
The Molecular Evolutionary Genetics Analysis (Mega) software implements many analytical methods and tools for phylogenomics and phylomedicine. Here, we report a transformation of Mega to enable cross-platform use on Microsoft Windows and Linux operating systems. Mega X does not require virtualization or emulation software and provides a uniform user experience across platforms. Mega X has additionally been upgraded to use multiple computing cores for many molecular evolutionary analyses. Mega X is available in two interfaces (graphical and command line) and can be downloaded from www.megasoftware.net free of charge.
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- Total evidence phylogeny of platyrrhine primates and a comparison of undated and tip-dating approaches
- Biogeographic problem-solving reveals the Late Pleistocene translocation of a short-faced bear to the California Channel Islands
- Genome of a middle Holocene hunter-gatherer from Wallacea
- Primordial Capsid and Spooled ssDNA Genome Structures Unravel Ancestral Events of Eukaryotic Viruses
- Lycosa Latreille, 1804 (Araneae, Lycosidae) of Israel, with a note on Geolycosa Montgomery, 1904
- Molecular Phylogenetics and Comparative Examination of Voucher Museums Reveal Two New Species of Gymnophthalmid Lizards (Squamata, Gymnophthalmidae) from the Peruvian Andes, with Comments on Proctoporus guentheri (Boettger, 1891)
- Hybridization in Canids—A Case Study of Pampas Fox (Lycalopex gymnocercus) and Domestic Dog (Canis lupus familiaris) Hybrid
- The Evaluations and Comparisons of Nuclear and Chloroplast DNA Regions Based on Species Identification and Phylogenetic Relationships of Crocus L. Taxa
- A 2-million-year-old ecosystem in Greenland uncovered by environmental DNA
- A robust phylogenetic framework for members of the order Legionellales and its main genera (Legionella, Aquicella, Coxiella and Rickettsiella) based on phylogenomic analyses and identification of molecular markers demarcating different clades
- The genetic basis of tail-loss evolution in humans and apes
- A new species of baleen whale (Balaenoptera) from the Gulf of Mexico, with a review of its geographic distribution
- AKAP14 is dispensable for mouse fertility
- Phylogenomic challenges in polyploid-rich lineages: Insights from paralog processing and reticulation methods using the complex genus Packera (Asteraceae: Senecioneae)
- Rice JASMONIC ACID OXIDASES control resting jasmonate metabolism to promote growth and repress basal immune responses
- Cobitis feroniae, a new spined loach from southern Latium, Italy (Teleostei: Cobitidae)
- Islands in the stream: Distribution of Myotis attenboroughi (Chiroptera, Vespertilionidae) in Grenada and mainland South America illuminates the evolutionary history of Caribbean Myotis
- A needle in a haystack: Rediscovery and revised description of Ichnotropis microlepidota Marx, 1956, from the central highlands of Angola
- Identifying the true number of specimens of the extinct blue antelope (Hippotragus leucophaeus)
- Toward a clarified taxonomy of Parentocirrus hortualis (Ciliophora, Hypotrichia): an integrative analysis of ontogenesis, ultrastructure, morphology, and molecular phylogeny
- Mitochondrial DNA Footprints from Western Eurasia in Modern Mongolia
- A new species of the genus Ivela Swinhoe (Lepidoptera, Erebidae, Lymantriinae) from Guangdong, China
- Boring Bivalves: Using Molecular Phylogenetics to Resolve Species Identities in Botula (Mytilidae)
- Characterization of ecdysteroid biosynthesis in the pond wolf spider, Pardosa pseudoannulata
- Ancient mitogenomics elucidates diversity of extinct West Indian tortoises
- Comparative transcriptomics in ferns reveals key innovations and divergent evolution of the secondary cell walls
- Spatial transcriptomics of a parasitic flatworm provides a molecular map of drug targets and drug resistance genes
- Diagnostic investigation of avian reovirus field variants circulating in broiler chickens in Pennsylvania of United States between 2017 and 2022
- Taxonomy and molecular phylogeny of Urocleidoides spp. (Monopisthocotyla: Dactylogyridae): Four new species and cophylogenetic patterns in a clade of species parasitizing Characiformes hosts
- First detection and molecular identification of a pathogenic spotted fever group Rickettsia, R. massiliae, from Rhipicephalus haemaphysaloides ticks infesting dogs in southern Taiwan
- Discovery of the potentially invasive Asian longhorned tick, Haemaphysalis longicornis Neumann (Acari: Ixodidae) in Türkiye: an unexpected finding through citizen science
- First detection and genetic identification of Rickettsia infection in Rhipicephalus sanguineus (Acari: Ixodidae) ticks collected from Southern Taiwan
- The Complete Mitochondrial Genome of Two Armored Catfish Populations of the Genus Hypostomus (Siluriformes, Loricariidae, Hypostominae)
- Bulk-bone ancient metagenomics reveals the transport of South Asian fish across the Himalayas in the 8th century CE
- Population structure of the endangered green turtles in a feeding ground in Brazilian Northeast: insights for conservation strategies
- Frogs of the Makuleke Contractual Park, northern Kruger National Park
- A new lineage of fresh‐ and brackish‐water mussels (Bivalvia, Mytilidae) from Southeast Asia
- Virome analysis of irrigation water sources provides extensive insights into the diversity and distribution of plant viruses in agroecosystems
- Nocardiopsis deserti sp. nov., isolated from a high altitude Atacama Desert soil
- First record of Tarzetta oblongispora (Pezizomycetes) in Türkiye
- Three novel species of Alternaria (Pleosporales, Pleosporaceae) from cereal crops (Poaceae) in China
- Pan-Genome Analysis Reveals Local Adaptation to Climate Driven by Introgression in Oak Species
- Neolithic genomes reveal a distinct ancient HLA allele pool and population transformation in Europe
- Probable Pangolin Origin of SARS-CoV-2 Associated with the COVID-19 Outbreak
- RNAi-mediated suppression of toll-like receptor NlToll1 enhances Nilaparvata lugens susceptibility to entomopathogenic fungal infection
- A new species of Characidium (Characiformes: Crenuchidae) from the Iguaçu National Park, Rio Iguaçu basin, Paraná, Brazil
- Strigolactones enhance apple drought resistance via the MsABI5-MsSMXL1-MsNAC022 cascade
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