The multifaceted role of SOCS3 in colorectal cancer: molecular mechanisms and clinical implications

2026/07/29 by Hesan Abbasi, Sepideh Razi, Nima Rezaei
Immunology and Microbiology · Medicine · #Cytokine #Cytokine Signaling Pathways and Interactions #Epigenetics #Janus kinase #Psoriasis: Treatment and Pathogenesis #Regulator #SOCS3 #STAT protein #STAT3 #Signal transduction #Suppressor of cytokine signaling 1 #Suppressor of cytokine signalling #interferon and immune responses

paper · doi:10.1007/s11033-026-12500-8

openalex publication_date 2026/07/29 · openalex created_date 2026/07/30 · openalex updated_date 2026/07/31

Citations

• IL-6-induced DNMT1 activity mediates SOCS3 promoter hypermethylation in ulcerative colitis-related colorectal cancer
• Suppressor of cytokine signaling (SOCS) proteins are induced by IL-7 and target surface CD127 protein for degradation in human CD8 T cells
• Promoter methylation and expression of SOCS3 affect the clinical outcome of pediatric acute lymphoblastic leukemia by JAK/STAT pathway
• Emerging roles of suppressor of cytokine signaling 3 in human cancers
• The role of suppressor of cytokine signaling 3 in inflammatory bowel disease and its associated colorectal cancer