2024/09/09 by Jacob Gildenblat, Gildenblat, Jacob, Ofir Hadar +1 · 1 citation
Computer Science · Medicine · #AI in cancer detection #Computer Vision and Pattern Recognition (cs.CV) #FOS: Computer and information sciences #Machine Learning (cs.LG) #Radiomics and Machine Learning in Medical Imaging
paper · pdf · doi:10.48550/arxiv.2409.05697
openalex publication_date 2024/09/09 · openalex created_date 2024/10/22 · openalex updated_date 2026/07/28
We introduce Segmentation by Factorization (F-SEG), an unsupervised segmentation method for pathology that generates segmentation masks from pre-trained deep learning models. F-SEG allows the use of pre-trained deep neural networks, including recently developed pathology foundation models, for semantic segmentation. It achieves this without requiring additional training or finetuning, by factorizing the spatial features extracted by the models into segmentation masks and their associated concept features. We create generic tissue phenotypes for H&E images by training clustering models for multiple numbers of clusters on features extracted from several deep learning models on The Cancer Genome Atlas Program (TCGA), and then show how the clusters can be used for factorizing corresponding segmentation masks using off-the-shelf deep learning models. Our results show that F-SEG provides robust unsupervised segmentation capabilities for H&E pathology images, and that the segmentation quality is greatly improved by utilizing pathology foundation models. We discuss and propose methods for evaluating the performance of unsupervised segmentation in pathology.