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Explaining Digital Pathology Models via Clustering Activations

2025/11/18 by Bajger, Adam, Obdržálek, Jan, Kůr, Vojtěch +4
Computer Science · #AI in cancer detection #Computer Vision and Pattern Recognition (cs.CV) #Explainable Artificial Intelligence (XAI) #FOS: Computer and information sciences #Generative Adversarial Networks and Image Synthesis

paper · doi:10.48550/arxiv.2511.14558

openalex publication_date 2025/11/18 · openalex created_date 2025/11/20 · openalex updated_date 2026/07/28

Abstract

We present a clustering-based explainability technique for digital pathology models based on convolutional neural networks. Unlike commonly used methods based on saliency maps, such as occlusion, GradCAM, or relevance propagation, which highlight regions that contribute the most to the prediction for a single slide, our method shows the global behaviour of the model under consideration, while also providing more fine-grained information. The result clusters can be visualised not only to understand the model, but also to increase confidence in its operation, leading to faster adoption in clinical practice. We also evaluate the performance of our technique on an existing model for detecting prostate cancer, demonstrating its usefulness.

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