The small GTPase Sar1, control centre of COPII trafficking

2023/02/04 by Sander E. Van der Verren, Giulia Zanetti · 24 citations
Biochemistry, Genetics and Molecular Biology · Medicine · #Biology #COPII #Cell biology #Cellular transport and secretion #Endoplasmic Reticulum Stress and Disease #Endoplasmic reticulum #GTPase #Golgi apparatus #Pancreatic function and diabetes #Secretory pathway

paper · pdf · doi:10.1002/1873-3468.14595

openalex created_date 2023/02/04 · openalex publication_date 2023/02/04 · openalex updated_date 2026/07/25

Abstract

Sar1 is a small GTPase of the ARF family. Upon exchange of GDP for GTP, Sar1 associates with the endoplasmic reticulum (ER) membrane and recruits COPII components, orchestrating cargo concentration and membrane deformation. Many aspects of the role of Sar1 and regulation of its GTP cycle remain unclear, especially as complexity increases in higher organisms that secrete a wider range of cargoes. This review focusses on the regulation of GTP hydrolysis and its role in coat assembly, as well as the mechanism of Sar1-induced membrane deformation and scission. Finally, we highlight the additional specialisation in higher eukaryotes and the outstanding questions on how Sar1 functions are orchestrated.

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