Mesenchymal stem cell-derived secretome in traumatic brain injury: Stage-specific paracrine mechanisms and translational challenges

2026/07/21 by Jingtao Huang, Wenjun Zhang, Guanlin Huang +7
Medicine · Neuroscience · #Barrier Structure and Function Studies #Mesenchymal stem cell #Mesenchymal stem cell research #Neurogenesis and neuroplasticity mechanisms #Paracrine signalling #Signal transduction #Stem cell #Traumatic brain injury

paper · doi:10.1016/j.expneurol.2026.115935

published in Experimental Neurology 405, 115935 (Elsevier BV)

openalex publication_date 2026/07/21 · openalex created_date 2026/07/22 · openalex updated_date 2026/07/25

Citations

• Microglia in the TBI brain: The good, the bad, and the dysregulated
• Anti-inflammatory protein TSG-6 secreted by activated MSCs attenuates zymosan-induced mouse peritonitis by decreasing TLR2/NF-κB signaling in resident macrophages
• Delayed transplantation of human marrow stromal cell-seeded scaffolds increases transcallosal neural fiber length, angiogenesis, and hippocampal neuronal survival and improves functional outcome after traumatic brain injury in rats
• Umbilical cord mesenchymal stem cell transplantation significantly improves neurological function in patients with sequelae of traumatic brain injury
• miR-21 alleviated apoptosis of cortical neurons through promoting PTEN-Akt signaling pathway in vitro after experimental traumatic brain injury
• Therapies targeting lipid peroxidation in traumatic brain injury