Anti-inflammatory protein TSG-6 secreted by activated MSCs attenuates zymosan-induced mouse peritonitis by decreasing TLR2/NF-κB signaling in resident macrophages
2011/05/07 by Hosoon Choi, Ryang Hwa Lee, Nikolay Bazhanov +2 · 648 citations
Medicine · #Biology #Cancer research #Cell biology #Immune system #Immunology #Inflammation #Innate immune system #Macrophage #Mesenchymal stem cell #Mesenchymal stem cell research #Neonatal Respiratory Health Research #Signal transduction #TLR2 #Tissue Engineering and Regenerative Medicine #Zymosan
paper · pdf · doi:10.1182/blood-2010-12-327353
published in Blood 118(2), 330-338 (Elsevier BV)
openalex publication_date 2011/05/07 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/01
Abstract
Human mesenchymal stem/progenitor cells (hMSCs) repair tissues and modulate immune systems but the mechanisms are not fully understood. We demonstrated that hMSCs are activated by inflammatory signals to secrete the anti-inflammatory protein, TNF-α-stimulated gene 6 protein (TSG-6) and thereby create a negative feedback loop that reduces inflammation in zymosan-induced peritonitis. The results demonstrate for the first time that TSG-6 interacts through the CD44 receptor on resident macrophages to decrease zymosan/TLR2-mediated nuclear translocation of the NF-κB. The negative feedback loop created by MSCs through TSG-6 attenuates the inflammatory cascade that is initiated by resident macrophages and then amplified by mesothelial cells and probably other cells of the peritoneum. Because inflammation underlies many pathologic processes, including immune responses, the results may explain the beneficial effects of MSCs and TSG-6 in several disease models.
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