Aberrant activity in retinal degeneration impairs central visual processing and relies on Cx36-containing gap junctions

2015/05/22 by Elena Ivanova, Christopher W. Yee, Christopher Yee +2 · 25 citations
Biochemistry, Genetics and Molecular Biology · Neuroscience · #Anatomy #Biochemistry #Biology #Cell biology #Connexins and lens biology #Electrophysiology #Gap junction #Intracellular #Neuroscience #Photoreceptor and optogenetics research #Retina #Retinal #Retinal Development and Disorders #Retinal degeneration

paper · doi:10.1016/j.exer.2015.05.013

openalex publication_date 2015/05/22 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/01

Cited by

• Origins of spontaneous activity in the degenerating retina. [europepmc]
• Blockade of pathological retinal ganglion cell hyperactivity improves optogenetically evoked light responses in rd1 mice. [europepmc]
• Increased phosphorylation of Cx36 gap junctions in the AII amacrine cells of RD retina. [europepmc]
• Spontaneous Oscillatory Rhythms in the Degenerating Mouse Retina Modulate Retinal Ganglion Cell Responses to Electrical Stimulation. [europepmc]
• A Novel Retinal Oscillation Mechanism in an Autosomal Dominant Photoreceptor Degeneration Mouse Model. [europepmc]
• Aberrant Activity in Degenerated Retinas Revealed by Electrical Imaging. [europepmc]
• A Variant of GJD2, Encoding for Connexin 36, Alters the Function of Insulin Producing β-Cells. [europepmc]
• Retinal remodeling in human retinitis pigmentosa. [europepmc]
• Dampening Spontaneous Activity Improves the Light Sensitivity and Spatial Acuity of Optogenetic Retinal Prosthetic Responses. [europepmc]
• Connexin43- and Pannexin-Based Channels in Neuroinflammation and Cerebral Neuropathies. [europepmc]
• Clinical Impact of Spontaneous Hyperactivity in Degenerating Retinas: Significance for Diagnosis, Symptoms, and Treatment. [europepmc]
• Retinoic Acid Induces Hyperactivity, and Blocking Its Receptor Unmasks Light Responses and Augments Vision in Retinal Degeneration. [europepmc]
• Domain-specific distribution of gap junctions defines cellular coupling to establish a vascular relay in the retina. [europepmc]
• Local photoreceptor degeneration causes local pathophysiological remodeling of retinal neurons. [europepmc]
• Residual Visual Responses in Patients With Retinitis Pigmentosa Revealed by Functional Magnetic Resonance Imaging. [europepmc]
• Melanopsin Driven Light Responses Across a Large Fraction of Retinal Ganglion Cells in a Dystrophic Retina. [europepmc]
• Network Architecture of Gap Junctional Coupling among Parallel Processing Channels in the Mammalian Retina. [europepmc]
• Blockade of Retinal Oscillations by Benzodiazepines Improves Efficiency of Electrical Stimulation in the Mouse Model of RP, rd10. [europepmc]
• Degeneration-Dependent Retinal Remodeling: Looking for the Molecular Trigger. [europepmc]
• The role of gap junctions in cell death and neuromodulation in the retina. [europepmc]
• Model-based comparison of current flow in rod bipolar cells of healthy and early-stage degenerated retina. [europepmc]
• Correlated Activity in the Degenerate Retina Inhibits Focal Response to Electrical Stimulation. [europepmc]
• Stage-Dependent Changes of Visual Function and Electrical Response of the Retina in the rd10 Mouse Model. [europepmc]
• Robust cone-mediated signaling persists late into rod photoreceptor degeneration. [europepmc]
• Implications of Neural Plasticity in Retinal Prosthesis. [europepmc]