2023/09/28 by Weistenhöfer, Wobbeke, Michaelsen, Sandra, Schriever-Schwemmer, Gerlinde +3
#571.95 Toxicology #571.95 Toxikologie #616.9803 Betriebs- und Arbeitsmedizin #616.9803 Industrial and occupational medicine #Arbeitsstoff #BAT value #BAT-Wert #Biologischer Arbeitsstoff-Toleranzwert #Biomonitoring #Dichlormethan #Dichloromethane #Entwicklungstoxizität #Freon 30 #Gefahrstoff #Methandichlorid #Methane dichloride #Methylenbichlorid #Methylenchlorid #Methylendichlorid #Methylene bichloride #Methylene chloride #Methylene dichloride #Schwangerschaftsgruppe #Toxizität #Urin #biological tolerance value #biomonitoring #developmental toxicity #fruchtschädigende Wirkung #hazardous substance #occupational exposure #pregnancy risk group #prenatal toxicity #toxicity #urine
paper · doi:10.34865/bb7509d8_3ad
In 2014, the German Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area re-evaluated the maximum workplace concentration (MAK value) of dichloromethane [75-09-2] and set a MAK value of 50 ml dichloromethane/m3 (180 mg/m3). In humans, exposure to 50 ml/m3 of dichloromethane led to CO-Hb levels in the range of 3%, which is above the endogenous CO-Hb range of 0.4–2.6% in non-smoking pregnant women. There is no information available on the CO-Hb level at which oxygen deficiency occurs in the foetal tissues. As a result, the possibility of prenatal toxicity cannot be excluded even if the MAK value of 50 ml dichloromethane/m3 is observed. Based on this finding, classification in Pregnancy Risk Group B has been confirmed. In 2015, the biological tolerance value (BAT value) of 500 μg dichloromethane/l blood was derived in correlation to the MAK value. Pregnancy Risk Group B is therefore also valid for the BAT value. The possibility of prenatal toxicity cannot be excluded even when adhering to the BAT value of 500 μg dichloromethane/l blood.