2010/05/04 by Alexander V. Yakubovich, A. V. Yakubovich, Yakubovich, A. V. +6
Biochemistry, Genetics and Molecular Biology · Physics and Astronomy · #Bacterial Genetics and Biotechnology #Biological Physics (physics.bio-ph) #Biomolecules (q-bio.BM) #Chemical Physics (physics.chem-ph) #FOS: Biological sciences #FOS: Physical sciences #Protein Structure and Dynamics #Protein purification and stability #Statistical Mechanics (cond-mat.stat-mech) #cond-mat.stat-mech #physics.bio-ph #physics.chem-ph #q-bio.BM
paper · pdf · doi:10.48550/arxiv.1005.0504
24 pages, 3 figures
openalex publication_date 2010/05/04 · arxiv created 2010/05/19 · arxiv updated 2010/05/20 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/28
We present a novel statistical mechanics formalism for the theoretical description of the process of protein folding↔unfolding transition in water environment. The formalism is based on the construction of the partition function of a protein obeying two-stage-like folding kinetics. Using the statistical mechanics model of solvation of hydrophobic hydrocarbons we obtain the partition function of infinitely diluted solution of proteins in water environment. The calculated dependencies of the protein heat capacities upon temperature are compared with the corresponding results of experimental measurements for staphylococcal nuclease and metmyoglobin.