2016/05/06 by Robert S. Sade, Sade, Robert S.
Physics and Astronomy · #FOS: Physical sciences #Soft Condensed Matter (cond-mat.soft) #cond-mat.soft
paper · pdf · doi:10.48550/arxiv.1605.02763
45 pages, 1 figure
arxiv created 2016/05/06 · arxiv updated 2016/05/11
Equations that govern the temperature-dependence of the rate constants, Gibbs energies,enthalpies, entropies and heat capacities of activation for folding and unfolding of spontaneously-folding fixed two-state systems have been derived using a procedure that treats the denatured and the native conformers as being confined to harmonic Gibbs energy wells. The notion that a two-state system is physically defined only for a set temperature range is introduced. The implications of this novel treatment for protein folding are discussed.